"When is Covid, Covid?", posted on September 11, 2020 by Elizabeth Spencer, Tom Jefferson, Jon Brassey, Carl Heneghan
When is Covid, Covid? September 11, 2020 Elizabeth Spencer, Tom Jefferson, Jon Brassey, Carl Heneghan We are constantly following the tally of Covid-19 cases. But one question won’t go away: when is Covid-19 actually Covid-19? Covid-19 was first identified as a severe disease-causing atypical pneumonia, accompanied by fever, cough and sometimes a range of other symptoms. The clinical features of the 41 patients infected with 2019 novel coronavirus in Wuhan included pneumonia with abnormal findings on chest CT. The agent was identified as SARS-CoV-2. Testing by RT-PCR has been globally implemented to identify RNA sequences thought to be unique to SARS-CoV-2. Worldwide case numbers are based on the reporting of the presence or absence of small RNA sequences of the SARS-CoV-2 genome. Some diseases can be diagnosed based on a test alone; most diseases, however, are defined by the cluster of symptoms and signs, in addition to test results. A recent review found that a single sympt